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Visit your doctor or health care professional for regular checks on your progress. You will need a regular breast and pelvic exam and Pap smear while on Estrace. You should also discuss the need for regular mammograms with your health care professional, and follow his or her guidelines for these tests.

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If you have any reason to think you are pregnant, stop taking Estrace right away and contact your doctor or health care professional.

Smoking increases the risk of getting a blood clot or having a stroke while you are taking Estrace, especially if you are more than 35 years old. You are strongly advised not to smoke.

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Estrace can increase the risk of developing a condition (endometrial hyperplasia) that may lead to cancer of the lining of the uterus. Taking progestins, another hormone drug, with Estrace lowers the risk of developing this condition. Therefore, if your uterus has not been removed (by a hysterectomy), your doctor may prescribe a progestin for you to take together with your estrogen. You should know, however, that taking estrogens with progestins may have additional health risks. You should discuss the use of estrogens and progestins with your health care professional to determine the benefits and risks for you.

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